Below are the 2 most recent journal entries recorded in gollinkambi880's InsaneJournal:

Wednesday, December 7th, 2011
4:10 am	A thing of caution on avodart Dr. Edwin Epstein conveys his concerns with all the recent type about Avodart for the off-label treating thinning hair, in this particular editorial piece written in the viewpoint with the prescribing physician. . . . Propecia vs. Avodart: Have in mind the facts It is a lot interesting within the use of Avodart (active component: Dutasteride) as an off-label medication for that treatment of hairloss. Since Dutasteride is simply approved to treat benign enlargement on the prostate, the off-label use to take care of baldness needs to be approached cautiously. Dutasteride is marketed as Avodart by Glaxo Smith Kline at a dosage of 0. 5mg. It truly is in gel capsule form, so cutting it up will likely be difficult, and must stay inside a cool place in order that they will not likely stick together. It costs $75-95 for any 30 days supply at 0. 5mg. I have prescribed Propecia since its FDA approval in 1997 to around 1000 patients, and also have put on the extender myself for upwards of 36 months without unwanted side effects. I believe that learning the risks and benefits associated with a medicine is critical to deciding whether or not oahu is the right option for the management of condition in question. Dr. Edwin S. Epstein Dr. Epstein has focused on hair restoration surgery since 1990 and is also Virginia's only surgeon Board Certified in Hair Restoration Surgery. He founded the Stuart Medical Group in 1994, which is both medical director and owner. He graduated Duke in 1972 and received his medical degree from Georgetown in 1977. He could be Board Certified through the American Board of Hair Restoration Surgery, and also the American Board of Urology. Dr. Epstein's website: http://www. buy metacam online stuartmed. com Let's compare some of the differences between Propecia (finasteride) and Avodart (dutasteride): Technique of Action Both block the organization of DHT from Testosterone, by inhibiting the enzyme 5-alpha reductase. Unlike Propecia (Merck) which inhibits the 5 AR-2 enzyme only, Avodart (Glaxo Smith Kline) inhibits both 5AR-2 and 5AR-1 enzymes. Biological Model Finasteride includes a biological model and dutasteride doesn't. This simply signifies that there exists a lot more safety data on Propecia than Avodart at the moment. The results of 5AR type 2 deficiency, (precisely the same environment Propecia creates) are already thoroughly studied for more than 25 years or so in the group of patients within the Dominican Republic. The long-term "side effects" are not any thinning hair, no cancer of the prostate. Patients with genetic 5AR-2 deficiency have no life-threatening disorders and there is no 5AR-2 within their brain tissue. Conversely, there is absolutely no biological model for 5AR type 1 deficiency, which Avodart creates, and there are measurable numbers of 5AR-1 inside the neural. Conclusion -- the blockage of 5AR-1 can have yet unknown neurological implications. Dosage Glaxo presented the outcome in the Phase II studies about 3 yrs. ago in a very closed session only to the investigators mixed up in study. From the concepts presented, the dutasteride side effects were much like the finasteride side effects (5 mg) tested dose. Dutasteride's sexual negative effects were in the array of 3-4% versus 1-2% for finasteride 1mg (Propecia) and 3-4% for finasteride 5mg (Proscar). The outcome on the phase II trials did reveal that 2. 5 mg of Avodart gave nearly 2-3 times more hair growth than finasteride did for a full 5 mg, resulting even in frontal regrowth in most men. However, these superior outcome was for a rather high 2. 5mg dosage. Both Finasteride and Dutasteride have was initially Prostate medications, but Dutasteride's prostate dose is definitely lower than the tested dose for hair loss. Glaxo is very much doing the complete opposite of Merck in this particular sense. Finasteride worked better around the prostate on the higher dose (5mg - Proscar), as well as for hair with a lower dose (1mg - Propecia). Dutasteride was published for your prostate on the lower dose (Avodart - 0. 5mg), and was tested with results on baldness at Half a dozen times the dose (2. 5mg). The greater the dose, the more potential for side effects. Discuss Dutasteride with other sites in our Antiandrogen Forums . Current Mood: recumbent (Comment on this)
3:53 am	Catapres (clonidine) drug information: dosage, unwanted side effects, drug interactions and user rev DRUG INTERACTIONS: Your doctor or pharmacist may already be mindful of any possible drug interactions and could be monitoring you for the children. Will not start, stop, or modify the dosage of the medicine before checking together with your doctor or pharmacist first. Before using this medication, educate doctor or pharmacist of prescription and nonprescription/herbal products you might use, especially of: cyclobenzaprine, other drugs that could slow the center rate (e. g. , digoxin, calcium channel blockers such as diltiazem, beta blockers including metoprolol), MAO inhibitors (e. g. , furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), tricyclic antidepressants (e. g. , amitriptyline, desipramine). Tell a medical expert or pharmacist in the event you also take drugs that cause drowsiness such as: certain antihistamines (e. g. , diphenhydramine), anti-seizure drugs (e. g. , carbamazepine, phenobarbital), medicine for sleep or anxiety (e. g. buy nasonex without a prescription , alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain-killer (e. g. , codeine), psychiatric medicines (e. g. , chlorpromazine, risperidone, trazodone). Check labels on your entire medicines (e. g. , cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs like ibuprofen for pain/fever reduction) given that they could have ingredients which could enhance your blood pressure. Many cough-and-cold products can also contain substances that cause drowsiness. Ask your pharmacist about using those products safely. This document won't contain all possible interactions. Therefore, before using this product, educate doctor or pharmacist of all products you employ. Have a number of all your medications together with you, and share their email list using your doctor and pharmacist. OVERDOSE: If overdose is suspected, speak to your local poison control center or hospital immediately. People in the usa can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, fast/slow/irregular heartbeat, slow/shallow breathing, seizures. NOTES: Do not share this medication web-sites. Lifestyle changes like stress reduction programs, exercise, and dietary changes may increase the effectiveness in this medicine. Speak with your doctor or pharmacist about change in lifestyle that may assist you. Check your blood pressure levels regularly while investing in this medication. Learn how to monitor your individual blood pressure levels at home, and share the effects using your doctor. MISSED DOSE: See also Utilizing section. If you miss a dose, go once you remember. Whether it's near the period of your next dose, skip the missed dose and resume your usual dosing schedule. Tend not to double the amount dose capture up. When you miss Two or more doses uninterruptedly, call your doctor immediately. STORAGE: Store at room temperature (77 degrees F or 25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store from the bathroom. Keep all medicines from children and pets. Do not flush medications around the toilet or pour them to a drain unless made to do it. Properly discard this system when it's expired or no longer needed. Talk to your pharmacist or local waste disposal company for additional information about how exactly to safely discard your product. MEDICAL ALERT: Your condition might cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada). Information last revised May 2010 Copyright(c) 2010 First DataBank, Inc. . Current Mood: confused (Comment on this)